Summary:
Recombinant human TIA1 protein
Cat：P02786
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-214aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TIA1 |
| 【Full Name】： cytotoxic granule-associated RNA binding protein |
| 【Uniprot】： P31483 |
| 【Gene ID】： 7072 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 24kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The product encoded by this gene is a member of a RNA-binding protein family and involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs).Possesses nucleolytic activity against cytotoxic lymphocyte target cells.It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets.The major granule-associated species is a 15-kDaa protein that is thought to be derived from the carboxyl terminus of the 40-kDaa product by proteolytic processing.Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
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