Summary:
Recombinant human OGG1 protein
Cat：P02796
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-345aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： OGG1 |
| 【Full Name】： 8-oxoguanine DNA glycosylase |
| 【Uniprot】： O15527 |
| 【Gene ID】： 4968 |
| 【Species Reactivity】： Human Mouse Rat (Fruit fly) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
DNA repair enzyme that incises DNA at 8-oxoG residues.Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA.Has a beta-lyase activity that nicks DNA 3' to the lesion.Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence.Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8.All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
Verified picture
