Summary:
Recombinant human TNNC1 protein
Cat：P02821
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-161aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TNNC1 |
| 【Full Name】： Troponin C，slow skeletal and cardiac muscles |
| 【Uniprot】： P63316 |
| 【Gene ID】： 7134 |
| 【Species Reactivity】： Human Mouse (Bovine Rabbit Pig Chicken) |
| 【Mol Mass】： 18kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament.Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene.The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.Mutations in this gene are associated with cardiomyopathy dilated type 1Z.
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