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Recombinant human CDK18 protein

Cat:P02825

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 125-474aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: CDK18
【Full Name】: Cyclin-dependent kinase 18
【Uniprot】: Q07002
【Gene ID】: 5129
【Species Reactivity】: Human Mouse Rat (Gorilla)
【Mol Mass】: 40kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

Human echinoderm microtubule-associated protein-like is a strong candidate for the Usher syndrome type 1A gene.Usher syndromes (USHs) are a group of genetic disorders consisting of congenital deafness, retinitis pigmentosa, and vestibular dysfunction of variable onset and severity depending on the genetic type.The disease process in USHs involves the entire brain and is not limited to the posterior fossa or auditory and visual systems.The USHs are catagorized as type I (USH1A, USH1B, USH1C, USH1D, USH1E and USH1F), type II (USH2A and USH2B) and type III (USH3).The type I is the most severe form.Gene loci responsible for these three types are all mapped.Two transcript variants encoding different isoforms have been found for this gene.

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