Summary:
Recombinant human MAN1B1 protein
Cat：P02866
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 359-698aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： MAN1B1 |
| 【Full Name】： Endoplasmic reticulum mannosyl-oligosaccharide 1，2-alpha-mannosidase |
| 【Uniprot】： Q9UKM7 |
| 【Gene ID】： 11253 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family.This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B.It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway.Mutations in this gene cause autosomal-recessive intellectual disability.Alternative splicing results in multiple transcript variants.A related pseudogene has been identified on chromosome 11.
Verified picture
