Summary:
Recombinant human CFB protein
Cat：P02887
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 51-400aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CFB |
| 【Full Name】： complement factor B |
| 【Uniprot】： P00751 |
| 【Gene ID】： 629 |
| 【Species Reactivity】： Human Mouse (Bovine Pig Gorilla) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes complement factor B, a component of the alternative pathway of complement activation.Factor B circulates in the blood as a single chain polypeptide.Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb.The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase.Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.This cluster includes several genes involved in regulation of the immune reaction.Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration.The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Verified picture
