Summary:
Recombinant human DSE protein
Cat：P02951
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 609-958aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： DSE |
| 【Full Name】： dermatan sulfate epimerase |
| 【Uniprot】： Q9UL01 |
| 【Gene ID】： 29940 |
| 【Species Reactivity】： Human Mouse (Bovine) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a tumor-rejection antigen.It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate.This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy.Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome.Alternative splicing results in multiple transcript variants.A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18.
Verified picture
