Summary:
Recombinant human ENSA protein
Cat：P02993
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-121aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ENSA |
| 【Full Name】： endosulfine alpha |
| 【Uniprot】： O43768 |
| 【Gene ID】： 2029 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Chicken Pig) |
| 【Mol Mass】： 13kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family.This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1.ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells.This protein is thought to be an endogenous regulator of KATP channels.In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes.At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.
Verified picture
