Summary:
Recombinant human NHP2 protein
Cat：P03005
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-153aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： NHP2 |
| 【Full Name】： H/ACA ribonucleoprotein complex subunit 2 |
| 【Uniprot】： Q9NX24 |
| 【Gene ID】： 55651 |
| 【Species Reactivity】： Human Mouse (Bovine Zebrafish Fruit fly Gorilla Monkey) |
| 【Mol Mass】： 17kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family.snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA.The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins.These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus.Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted.The four H/ACA snoRNP proteins are also components of the telomerase complex.This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p.Alternative splicing results in multiple transcript variants.
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