Summary:
Recombinant human ABAT protein
Cat：P03006
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-116aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ABAT |
| 【Full Name】： 4-aminobutyrate aminotransferase |
| 【Uniprot】： / |
| 【Gene ID】： 18 |
| 【Species Reactivity】： / |
| 【Mol Mass】： 13kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate.The protein sequence is over 95% similar to the pig protein.GABA is estimated to be present in nearly one-third of human synapses.ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44.The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities.Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Verified picture
