Summary:
Recombinant human GPX1 protein
Cat：P03044
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 59-203aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： GPX1 |
| 【Full Name】： glutathione peroxidase 1 |
| 【Uniprot】： P07203 |
| 【Gene ID】： 2876 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Pig Rabbit Chicken) |
| 【Mol Mass】： 16kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage.Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes.Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity.This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide.It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site.Sec is encoded by the UGA codon, which normally signals translation termination.The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop s
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