Summary:
Recombinant human ILF3 protein
Cat：P03060
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-353aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ILF3 |
| 【Full Name】： Interleukin enhancer-binding factor 3 |
| 【Uniprot】： Q12906 |
| 【Gene ID】： 3609 |
| 【Species Reactivity】： Human Mouse Rat (Zebrafish) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs.This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2.This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm.Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization.In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced.Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Verified picture
