Summary:
Recombinant human SKP1 protein
Cat：P03102
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-163aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： SKP1 |
| 【Full Name】： S-phase kinase-associated protein 1 |
| 【Uniprot】： P63208 |
| 【Gene ID】： 6500 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Chicken Pig Monkey Gorilla) |
| 【Mol Mass】： 19kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins.This protein binds directly to the F-box motif found in F-box proteins.SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome.Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development.Studies have also characterized the protein as an RNA polymerase II elongation factor.Alternative splicing of this gene results in two transcript variants.A related pseudogene has been identified on chromosome 7.
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