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Recombinant human ISCU protein

Cat：P03113

Summary:

【Derived From】： E.coli

【Endotoxin】： Not measured

【Amino Acid】： 1-167aa

【Purity】： ≥85% by SDS-PAGE.

【Name】： ISCU

【Full Name】： iron-sulfur cluster scaffold homolog (E. coli)

【Uniprot】： Q9H1K1

【Gene ID】： 23479

【Species Reactivity】： Human Mouse

【Mol Mass】： 18kDa

【Application】： Immunology research

【Purification】： NI-NTA affinity purification

【Bioactive】： N0

【Tag】： With a 6×His tag at the N/C-terminus.

【Concentration】： 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)

【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year.

【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold.Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response.Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion.Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis.A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein.A pseudogene of this gene is present on chromosome 1.

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