Summary:
Recombinant human CLPTM1 protein
Cat：P03127
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-350aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CLPTM1 |
| 【Full Name】： cleft lip and palate associated transmembrane protein 1 |
| 【Uniprot】： O96005 |
| 【Gene ID】： 1209 |
| 【Species Reactivity】： Human Mouse (Bovine Zebrafish Chicken Gorilla) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17.Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils.It causes the release of histamine from basophils and activates eosinophils.This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells.It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.Alternative splicing results in multiple transcript variants that encode different isoforms
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