Summary:
Recombinant human NME1 protein
Cat：P03132
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-152aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： NME1 |
| 【Full Name】： non-metastatic cells 1 |
| 【Uniprot】： P15531 |
| 【Gene ID】： 4830 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Dog Gorilla) |
| 【Mol Mass】： 17kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells.Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms.Mutations in this gene have been identified in aggressive neuroblastomas.Two transcript variants encoding different isoforms have been found for this gene.Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
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