Summary:
Recombinant human PPM1B protein
Cat：P03190
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-193aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PPM1B |
| 【Full Name】： protein phosphatase 1B (formerly 2C)，magnesium-dependent，beta isoform |
| 【Uniprot】： O75688 |
| 【Gene ID】： 5495 |
| 【Species Reactivity】： Human Mouse Rat (Bovine) |
| 【Mol Mass】： 21kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： No activity experimental data, to be verified. |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases.PP2C family members are known to be negative regulators of cell stress response pathways.This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control.Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death.Alternative splicing results in multiple transcript variants encoding different isoforms.Additional transcript variants have been described, but currently do not represent full-length sequences.
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