Summary:
Recombinant human TIRAP protein
Cat：P03191
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-257aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TIRAP |
| 【Full Name】： toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
| 【Uniprot】： P58753 |
| 【Gene ID】： 114609 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 28kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： No activity experimental data, to be verified. |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns.Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction.The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system.It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response.Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
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