Summary:
Recombinant human SETMAR protein
Cat：P03261
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-353aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： SETMAR |
| 【Full Name】： SET domain and mariner transposase fusion gene |
| 【Uniprot】： Q53H47 |
| 【Gene ID】： 6419 |
| 【Species Reactivity】： Human Mouse Rat (Gorilla Sheep) |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain.The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair.The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36.This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain.Alternate splicing results in multiple transcript variants.
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