Summary:
Recombinant human LECT1 protein
Cat：P03264
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 66-333aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： LECT1 |
| 【Full Name】： leukocyte cell derived chemotaxin 1 |
| 【Uniprot】： O75829 |
| 【Gene ID】： 11061 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Rabbit Chicken) |
| 【Mol Mass】： 37kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein.The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it.The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1.The mature protein promotes chondrocyte growth and inhibits angiogenesis.This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion.The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone.It may be involved also in the broad control of tissue vascularization during development.Alternative splicing results in multiple transcript variants encoding different isoforms.
Verified picture
