Summary:
Recombinant human CLASP1 protein
Cat：P03280
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-150aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CLASP1 |
| 【Full Name】： cytoplasmic linker associated protein 1 |
| 【Uniprot】： Q7Z460 |
| 【Gene ID】： 23332 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 17kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN).Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell.May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2.This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling.Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle.
Verified picture
