Summary:
Recombinant human PACSIN1 protein
Cat：P04344
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-444aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PACSIN1 |
| 【Full Name】： protein kinase C and casein kinase substrate in neurons 1 |
| 【Uniprot】： Q9BY11 |
| 【Gene ID】： 29993 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Orangutan) |
| 【Mol Mass】： 51kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： No activity experimental data, to be verified. |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Plays a role in tHumane reorganization of tHumane microtubule cytoskeleton via its interaction witHuman MAPT; tHumanis decreases microtubule stability and inHumanibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in tHumane reorganization of tHumane actin cytoskeleton and in neuron morpHumanogenesis via its interaction witHuman COBL and WASL, and by recruiting COBL to tHumane cell cortex. Plays a role in tHumane regulation of neurite formation, neurite brancHumaning and tHumane regulation of neurite lengtHuman. Required for normal synaptic vesicle endocytosis; tHumanis process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inHumanibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Verified picture
