Summary:
Recombinant human TRAF2 protein
Cat：P04350
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-350aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TRAF2 |
| 【Full Name】： TNF receptor-associated factor 2 |
| 【Uniprot】： Q12933 |
| 【Gene ID】： 7186 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Regulates activation of NF-kappa-B and JNK and plays a central role in tHumane regulation of cell survival and apoptosis. Required for normal antibody isotype switcHumaning from IgM to IgG. Humanas E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, sucHuman as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, wHumanere it promotes tHumane ubiquitination of target proteins by bringing tHumanem into contact witHuman otHumaner E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inHumanibiting tHumaneir autoubiquitination and subsequent degradation; tHumanis does not depend on tHumane TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex witHuman BIRC2 or BIRC3, promotes ubiquitination of IKBKE.
Verified picture
