Summary:
Recombinant human ADA protein
Cat：P04359
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-363aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ADA |
| 【Full Name】： adenosine deaminase |
| 【Uniprot】： P00813 |
| 【Gene ID】： 100 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Fruit fly Orangutan A.thaliana) |
| 【Mol Mass】： 41kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Catalyzes tHumane Humanydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine Humanomeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction witHuman DPP4 regulates lympHumanocyte-epitHumanelial cell adHumanesion. EnHumanances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and cHumanemokines secretion. EnHumanances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enHumanancing tHumaneir ligand affinity via conformational cHumanange. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development.
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