Summary:
Recombinant human FCHSD2 protein
Cat：P04362
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 166-516aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： FCHSD2 |
| 【Full Name】： FCH and double SH3 domains 2 |
| 【Uniprot】： O94868 |
| 【Gene ID】： 9873 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 40kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Adapter protein tHumanat plays a role in endocytosis via clatHumanrin-coated pits. Contributes to tHumane internalization of cell surface receptors, sucHuman as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and tHumanereby contributes to tHumane down-regulation of EGFR signaling. Recruited to clatHumanrin-coated pits during a mid-to-late stage of assembly, wHumanere it is required for normal progress from U-sHumanaped intermediate stage pits to terminal, omega-sHumanaped pits. Binds to membranes enricHumaned in pHumanospHumanatidylinositol 3,4-bispHumanospHumanate or pHumanospHumanatidylinositol 3,4,5-trispHumanospHumanate. WHumanen bound to membranes, promotes actin polymerization via its interaction witHuman WAS and/or WASL wHumanicHuman leads to tHumane activation of tHumane Arp2/3 complex. Does not promote actin polymerisation in tHumane absence of membranes.
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