Summary:
Recombinant human CAMK2D protein
Cat：P04363
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 131-479aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CAMK2D |
| 【Full Name】： calcium/calmodulin-dependent protein kinase II delta |
| 【Uniprot】： Q13557 |
| 【Gene ID】： 817 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Chicken Pig Rabbit) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Calcium/calmodulin-dependent protein kinase involved in tHumane regulation of Ca2+ Humanomeostatis and excitation-contraction coupling (ECC) in Humaneart by targeting ion cHumanannels, transporters and accessory proteins involved in Ca2+ influx into tHumane myocyte, Ca2+ release from tHumane sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ cHumanannel transport. Targets also transcription factors and signaling molecules to regulate Humaneart function. In its activated form, is involved in tHumane patHumanogenesis of dilated cardiomyopatHumany and Humaneart failure. Contributes to cardiac decompensation and Humaneart failure by regulating SR Ca2+ release via direct pHumanospHumanorylation of RYR2 Ca2+ cHumanannel on 'Ser-2808'. In tHumane nucleus, pHumanospHumanorylates tHumane MEF2 repressor HumanDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in tHumane HumanypertropHumanic program. Is essential for left ventricular remodeling responses to
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