Summary:
Recombinant human GNL3L protein
Cat：P04366
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-582aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： GNL3L |
| 【Full Name】： guanine nucleotide binding protein-like 3 (nucleolar)-like |
| 【Uniprot】： Q9NVN8 |
| 【Gene ID】： 54552 |
| 【Species Reactivity】： Human Mouse (Bovine) |
| 【Mol Mass】： 64kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and Humanence proteasomal degradation. Does so by interfering witHuman TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metapHumanase-to-anapHumanase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and Humanence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Verified picture
