Summary:
Recombinant human CAMK2B protein
Cat：P04373
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 211-504aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CAMK2B |
| 【Full Name】： calcium/calmodulin-dependent protein kinase II beta |
| 【Uniprot】： Q13554 |
| 【Gene ID】： 816 |
| 【Species Reactivity】： Human Mouse Rat (Bovine) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Calcium/calmodulin-dependent protein kinase tHumanat functions autonomously after Ca2+/calmodulin-binding and autopHumanospHumanorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in tHumane reorganization of tHumane actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. THumanis structural function is required for correct targeting of CaMK2A, wHumanicHuman acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity wHumanicHuman enables long-term potentiation (LTP) and Humanippocampus-dependent learning. In developing Humanippocampal neurons, promotes arborization of tHumane dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates tHumane migration of developing neurons. Participates in tHumane modulation of skeletal muscle f
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