Summary:
Recombinant human MAPK15 protein
Cat：P04837
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-277aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： MAPK15 |
| 【Full Name】： mitogen-activated protein kinase 15 |
| 【Uniprot】： Q8TD08 |
| 【Gene ID】： 225689 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 31.1kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Atypical MAPK protein that regulates several process such as autophagy，ciliogenesis，protein trafficking/secretion and genome integrity，in a kinase activity-dependent manner (PubMed:22948227，PubMed:24618899，PubMed:29021280，PubMed:21847093，PubMed:20733054).Controls both，basal and starvation-induced autophagy throught its interaction with GABARAP，MAP1LC3B and GABARAPL1 leading to autophagosome formation，SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227).Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure，transport，and signaling (PubMed:29021280).Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum，thereby restricting the production of sugar-coated proteins (PubMed:24618899).Upon amino-acid starvation，mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion (PubMed:21847093).Binds to chromatin leading to MAPK15 activation and
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