Summary:
Recombinant human PMAIP1 protein
Cat：P03346
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-54aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PMAIP1 |
| 【Full Name】： phorbol-12-myristate-13-acetate-induced protein 1 |
| 【Uniprot】： Q13794 |
| 【Gene ID】： 5366 |
| 【Species Reactivity】： Human Rat (Bovine Dog) |
| 【Mol Mass】： 6kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Promotes activation of caspases and apoptosis.Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria.Contributes to p53/TP53-dependent apoptosis after radiation exposure.Promotes proteasomal degradation of MCL1.Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity).Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Verified picture
