Summary:
Recombinant human RNASEH2B protein
Cat：P03380
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-312aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RNASEH2B |
| 【Full Name】： ribonuclease H2，subunit B |
| 【Uniprot】： Q5TBB1 |
| 【Gene ID】： 79621 |
| 【Species Reactivity】： Human Mouse Rat (Bovine) |
| 【Mol Mass】： 35kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids.The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication.Multiple transcript variants encoding different isoforms have been found for this gene.Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).
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