Summary:
Recombinant human RHBDD1 protein
Cat：P03385
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-106aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： RHBDD1 |
| 【Full Name】： rhomboid domain containing 1 |
| 【Uniprot】： Q8TEB9 |
| 【Gene ID】： 84236 |
| 【Species Reactivity】： Human Mouse Rat (Gorilla) |
| 【Mol Mass】： 12kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions.Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins.Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins.Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner.Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing.Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway.Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity.Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spe
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