Summary:
Recombinant human COPS2 protein
Cat：P03409
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-440aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： COPS2 |
| 【Full Name】： COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) |
| 【Uniprot】： P61201 |
| 【Gene ID】： 9318 |
| 【Species Reactivity】： Human Mouse Rat (Zebrafish) |
| 【Mol Mass】： 50kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Verified picture
