Summary:
Recombinant human FDPS protein
Cat：P03439
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-419aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： FDPS |
| 【Full Name】： farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase，dimethylallyltranstransferase，geranyltranstransferase) |
| 【Uniprot】： P14324 |
| 【Gene ID】： 2224 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Chicken) |
| 【Mol Mass】： 48kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate.The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors.Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption.Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X.Multiple transcript variants encoding different isoforms have been found for this gene.
Verified picture
