Summary:
Recombinant human ALDH4A1 protein
Cat：P03450
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 214-563aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ALDH4A1 |
| 【Full Name】： aldehyde dehydrogenase 4 family，member A1 |
| 【Uniprot】： P30038 |
| 【Gene ID】： 8659 |
| 【Species Reactivity】： Human (Bovine Mouse Rat Zebrafish) |
| 【Mol Mass】： 38kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling.Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules.Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex.Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles.Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells.May be required for the lysosomal retention of FASLG/FASL.
Verified picture
