Summary:
Recombinant human ERH protein
Cat：P03484
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-104aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： ERH |
| 【Full Name】： enhancer of rudimentary homolog (Drosophila) |
| 【Uniprot】： P84090 |
| 【Gene ID】： 2079 |
| 【Species Reactivity】： Human Mouse (Bovine Pig Zebrafish A.thaliana) |
| 【Mol Mass】： 12kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
ERH (enhancer of rudimentary homolog), also known as DROER, is a 104 amino acid transcriptional coregulator that is ubiquitously expressed and highly conserved among eukaryotes.ERH may play a role in cell cycle regulation and pyrimidine biosynthesis.ERH represses the function of the coactivator PCBD, preventing it from enhancing the activity of the tissue-specific transcription factor HNF-1 (hepatocyte nuclear factor-1).HNF-1 is a homeodomain transcription factor that binds DNA as a dimer and the HNF-1/DNA complex is stabilized by PCBD.By repressing PCBD, ERH disrupts the stability of the HNF-1/DNA complex, affecting the expression of multiple genes in the liver.The structure of ERH is characterized by a single domain consisting of three alpha-helices and four beta-strands.ERH has a long flexible loop that is significantly conserved, suggesting that this loop region may be important for the function of ERH.ERH has two casein kinase II phosphorylation sites that are thought to disrupt the ability of ERH to dim
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