Summary:
Recombinant human CUTA protein
Cat：P03502
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-179aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CUTA |
| 【Full Name】： cutA divalent cation tolerance homolog (E. coli) |
| 【Uniprot】： O60888 |
| 【Gene ID】： 51596 |
| 【Species Reactivity】： Human Mouse Rat (Bovine A.thaliana) |
| 【Mol Mass】： 19kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
CUTA, also known as ACHAP (acetylcholinesterase-associated protein), is the 179 amino acid mammalian homolog of the cutA E.coli protein and is ubiquitously expressed, particularly in brain tissue.Existing as multiple alternatively spliced isoforms, CUTA functions as a homotrimer that is thought to act as a component of an acetylcholinesterase (AChE)-attached complex, suggesting an involvement in AChE regulation.The gene encoding CUTA maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus.Additionally, Porphyria cutanea tarda, Parkinson’s disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
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