Summary:
Recombinant human TCEB2 protein
Cat：P03539
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-118aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： TCEB2 |
| 【Full Name】： transcription elongation factor B (SIII)，polypeptide 2 (18kDa，elongin B) |
| 【Uniprot】： Q15370 |
| 【Gene ID】： 6923 |
| 【Species Reactivity】： Human Mouse Rat |
| 【Mol Mass】： 13kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex.The SIII complex is composed of elongins A/A2, B and C.It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units.Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits.Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C.The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.Pseudogenes have been identified on chromosomes 11 and 13.
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