Summary:
Recombinant human COX7A2L protein
Cat：P03579
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-114aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： COX7A2L |
| 【Full Name】： cytochrome c oxidase subunit VIIa polypeptide 2 like |
| 【Uniprot】： O14548 |
| 【Gene ID】： 9167 |
| 【Species Reactivity】： Human Mouse (Bovine) |
| 【Mol Mass】： 13kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence.This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment.It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.
Verified picture
