下载

Recombinant human NDUFV1 protein

Cat：P03648

Summary:

【Derived From】： E.coli

【Endotoxin】： Not measured

【Amino Acid】： 115-449aa

【Purity】： ≥85% by SDS-PAGE.

【Name】： NDUFV1

【Full Name】： NADH dehydrogenase (ubiquinone) flavoprotein 1，51kDa

【Uniprot】： P49821

【Gene ID】： 4723

【Species Reactivity】： Human Mouse Rat (Bovine Fruit fly)

【Mol Mass】： 39kDa

【Application】： Immunology research

【Purification】： NI-NTA affinity purification

【Bioactive】： N0

【Tag】： With a 6×His tag at the N/C-terminus.

【Concentration】： 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)

【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year.

【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V).This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone.This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites.Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births.Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome.Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Verified picture