Summary:
Recombinant human HNRNPK protein
Cat：P03664
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 114-463aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： HNRNPK |
| 【Full Name】： heterogeneous nuclear ribonucleoprotein K |
| 【Uniprot】： P61978 |
| 【Gene ID】： 3190 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Chicken Gorilla Rabbit Monkey) |
| 【Mol Mass】： 39kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.The hnRNP proteins have distinct nucleic acid binding properties.The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs.It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C).This protein is also thought to have a role during cell cycle progession.Several alternatively spliced transcript variants have been described for this gene, however, not all of them are fully characterized.
Verified picture
