Summary:
Recombinant human CRADD protein
Cat：P03696
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-199aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： CRADD |
| 【Full Name】： CASP2 and RIPK1 domain containing adaptor with death domain |
| 【Uniprot】： P78560 |
| 【Gene ID】： 8738 |
| 【Species Reactivity】： Human Mouse (Gorilla) |
| 【Mol Mass】： 23kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a protein containing a death domain (DD) motif.This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis.A mutation in this gene was associated with cognitive disability.A related pseudogene is found on chromosome 3.Alternative splicing results in multiple transcript variants.
Verified picture
