Summary:
Recombinant human PDK3 protein
Cat：P03715
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-407aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PDK3 |
| 【Full Name】： pyruvate dehydrogenase kinase，isozyme 3 |
| 【Uniprot】： Q15120 |
| 【Gene ID】： 5165 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 47kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration.Can also phosphorylate PDHA2.Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet.Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation.Plays a role in the generation of reactive oxygen species.
Verified picture
