Summary:
Recombinant human HAAO protein
Cat：P03816
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-286aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： HAAO |
| 【Full Name】： 3-hydroxyanthranilate 3，4-dioxygenase |
| 【Uniprot】： P46952 |
| 【Gene ID】： 23498 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Zebrafish Cat Pig Horse) |
| 【Mol Mass】： 33kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron.It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system.HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid.QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors.Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders.HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Verified picture
