Summary:
Recombinant human PLEKHO1 protein
Cat：P03821
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-409aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PLEKHO1 |
| 【Full Name】： pleckstrin homology domain containing，family O member 1 |
| 【Uniprot】： Q53GL0 |
| 【Gene ID】： 51177 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Chicken Zebrafish) |
| 【Mol Mass】： 46kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1 and SMURF1.It plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).Appears to target ATM to the plasma membrane,and also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival.The protein implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF.When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
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