Summary:
Recombinant human DKK1 protein
Cat：P03833
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-266aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： DKK1 |
| 【Full Name】： Dickkopf-related protein 1 |
| 【Uniprot】： O94907 |
| 【Gene ID】： 22943 |
| 【Species Reactivity】： Human Mouse |
| 【Mol Mass】： 29kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene encodes a member of the dickkopf family of proteins.Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions.The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling.This gene plays a role in embryonic development and may be important in bone formation in adults.Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines.
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