Summary:
Recombinant human KRT222P protein
Cat：P03851
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-295aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： KRT222P |
| 【Full Name】： Keratin-like protein KRT222 |
| 【Uniprot】： Q8N1A0 |
| 【Gene ID】： 125113 |
| 【Species Reactivity】： Human |
| 【Mol Mass】： 34kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
KRT222, also known as KRT222P.KRT222 is a 295 amino acid protein belonging to the intermediate filament family.The gene encoding KRT222P has been listed as a pseudogene, however it has not been established that the protein is not translated, and is therefore treated as a protein coding gene.Existing as two alternatively spliced isoforms, the gene encoding KRT222P maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1.Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death.Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopia
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