Summary:
Recombinant human GADD45A protein
Cat：P03863
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-165aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： GADD45A |
| 【Full Name】： growth arrest and DNA-damage-inducible，alpha |
| 【Uniprot】： P24522 |
| 【Gene ID】： 1647 |
| 【Species Reactivity】： Human Mouse Rat (Bovine Cat) |
| 【Mol Mass】： 18kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： N0 |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents.The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase.The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms.Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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