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Recombinant human KLHL12 protein

Cat:P03886

Summary:

【Derived From】: E.coli
【Endotoxin】: Not measured
【Amino Acid】: 219-568aa
【Purity】: ≥85% by SDS-PAGE.
【Name】: KLHL12
【Full Name】: Kelch-like protein 12
【Uniprot】: Q53G59
【Gene ID】: 59349
【Species Reactivity】: Human Mouse Rat (Bovine Zebrafish)
【Mol Mass】: 38kDa
【Application】: Immunology research
【Purification】: NI-NTA affinity purification
【Bioactive】: N0
【Tag】: With a 6×His tag at the N/C-terminus.
【Concentration】: 1mg/ml by SDS-PAGE.

Store:

【Reconstitution】: Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
【Storage】: Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year.
【Formulation】: Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0.

Background:

This gene encodes a member of the KLHL (Kelch-like) family of proteins.This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis.This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation.Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size.A pseudogene has been identified on chromosome 22.Alternative splicing results in multiple transcript variants.

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