Summary:
Recombinant human PCDHGC3 protein
Cat：P03889
| 【Derived From】： E.coli |
| 【Endotoxin】： Not measured |
| 【Amino Acid】： 1-61aa |
| 【Purity】： ≥85% by SDS-PAGE. |
| 【Name】： PCDHGC3 |
| 【Full Name】： protocadherin gamma subfamily C，3 |
| 【Uniprot】： Q9UN70 |
| 【Gene ID】： 5098 |
| 【Species Reactivity】： Human (Gorilla) |
| 【Mol Mass】： 7kDa |
| 【Application】： Immunology research |
| 【Purification】： NI-NTA affinity purification |
| 【Bioactive】： No activity experimental data, to be verified. |
| 【Tag】： With a 6×His tag at the N/C-terminus. |
| 【Concentration】： 1mg/ml by SDS-PAGE. |
Store:
| 【Reconstitution】： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| 【Storage】： Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| 【Formulation】： Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Background:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five.These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.The gamma gene cluster includes 22 genes divided into 3 subfamilies.Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes.The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster.Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region.The constant region exons encode the common cytoplasmic region.These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.Alternative splicing has been described for the g
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